Retinoid Targeting of Different D-Type Cyclins through Distinct Chemopreventive Mechanisms
نویسندگان
چکیده
منابع مشابه
Retinoid targeting of different D-type cyclins through distinct chemopreventive mechanisms.
D-type cyclins (cyclins D1, D2, and D3) promote G1-S progression and are aberrantly expressed in cancer. We reported previously that all-trans-retinoic acid chemo-prevented carcinogenic transformation of human bronchial epithelial (HBE) cells through proteasomal degradation of cyclin D1. Retinoic acid is shown here to activate distinct mechanisms to regulate different D-type cyclins in HBE cell...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2005
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-05-0370